Desoxo-narchinol A ( —— )

产品货号. M31583 CAS No. 53859-06-6

COA

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HNMR

HPLC

MSDS

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产品名称

Desoxo-narchinol A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.
产品描述

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.
体外实验

Desoxo-narchinol A inhibits tissue injury and production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in the liver and lung.Desoxo-narchinol A (0-500 nM, 24 h) inhibits the production of inflammatory mediators, such as iNOS and its derivative NO, COX-2, PGE2, IL-1β, IL-6 and TNF-α and H3 protein acetylation in murine peritoneal macrophages.Desoxo-narchinol A inhibits LPS-induced activation of p38 in murine macrophages.
体内实验

Desoxo-narchinol A (0-0.5 mg/kg, IP, once) dramatically reduced mortality in a murine LPS-induced endotoxin shock model. Desoxo-narchinol A (50 mg/kg, PO, once) shows the oral bioavailability of 18.1% in rats and 28.4% in mice
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